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phenobarbital will lower the level or influence of diazepam buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Powerful or average CYP3A4 inducers may possibly maximize rate of diazepam elimination; as a result, efficacy of diazepam may be reduced.Phenobarbital is actually a barbituric acid derivative for oral adm